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HERO ID
2290077
Reference Type
Journal Article
Title
SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage
Author(s)
Tseng, AHH; Shieh, SShu; Wang, DL
Year
2013
Is Peer Reviewed?
Yes
Journal
Free Radical Biology and Medicine
ISSN:
0891-5849
EISSN:
1873-4596
Volume
63
Page Numbers
222-234
PMID
23665396
DOI
10.1016/j.freeradbiomed.2013.05.002
Web of Science Id
WOS:000323094700020
Abstract
Progressive accumulation of defective mitochondria is a common feature of aged cells. SIRT3 is a NAD(+)-dependent protein deacetylase that regulates mitochondrial function and metabolism in response to caloric restriction and stress. FOXO3 is a direct target of SIRT3 and functions as a forkhead transcription factor to govern diverse cellular responses to stress. Here we show that hydrogen peroxide induces SIRT3 to deacetylate FOXO3 at K271 and K290, followed by the upregulation of a set of genes that are essential for mitochondrial homeostasis (mitochondrial biogenesis, fission/fusion, and mitophagy). Consequently, SIRT3-mediated deacetylation of FOXO3 modulates mitochondrial mass, ATP production, and clearance of defective mitochondria. Thus, mitochondrial quantity and quality are ensured to maintain mitochondrial reserve capacity in response to oxidative damage. Maladaptation to oxidative stress is a major risk factor underlying aging and many aging-related diseases. Hence, our finding that SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative stress provides a possible direction for aging-delaying therapies and disease intervention. (C) 2013 Elsevier Inc. All rights reserved.
Keywords
SIRT3; FOXO3; Mitochondrial homeostasis; Mitochondrial biogenesis; Mitochondrial fission/fusion; Mitophagy; Aging; Oxidative stress; Free radicals
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