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HERO ID
2303428
Reference Type
Journal Article
Title
Final Report of the Cosmetic Ingredient Review Expert Panel on the Safety Assessment of Dicarboxylic Acids, Salts, and Esters
Author(s)
Fiume, MM; Eldreth, H; Bergfeld, WF; Belsito, DV; Hill, RA; Klaassen, CD; Liebler, D; Marks, JG, Jr; Shank, RC; Slaga, TJ; Snyder, PW; Andersen, FA
Year
2012
Is Peer Reviewed?
Yes
Journal
International Journal of Toxicology
ISSN:
1091-5818
EISSN:
1092-874X
Volume
31
Issue
4 Suppl
Page Numbers
5S-76S
Language
English
PMID
22869895
DOI
10.1177/1091581812447203
Web of Science Id
WOS:000328700500001
Abstract
The CIR Expert Panel assessed the safety of dicarboxylic acids and their salts and esters as used in cosmetics. Most dicarboxylic acids function in cosmetics as pH adjusters or fragrance ingredients, but the functions of most of the salts in cosmetics are not reported. Some of the esters function as skin conditioning or fragrance ingredients, plasticizers, solvents, or emollients. The Expert Panel noted gaps in the available safety data for some of the dicarboxylic acid and their salts and esters in this safety assessment. The available data on many of the ingredients are sufficient, however, and similar structural activity relationships, biologic functions, and cosmetic product usage suggest that the available data may be extrapolated to support the safety of the entire group. The Panel concluded that the ingredients named in this report are safe in the present practices of use and concentration.
Keywords
final report of the cosmetic ingredient review expert panel on the safety assessment of dicarboxylic acids; salts and esters; safety; cosmetics
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