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HERO ID
2321108
Reference Type
Journal Article
Title
Prenatal developmental toxicity study of ethyl tertiary-butyl ether in rats
Author(s)
Aso, S; Miyata, K; Takakura, S; Hoshuyama, S; Muroi, T; Kusune, Y; Ajimi, S; Furukawa, K
Year
2014
Is Peer Reviewed?
Yes
Journal
Drug and Chemical Toxicology
ISSN:
0148-0545
EISSN:
1525-6014
Volume
37
Issue
1
Page Numbers
17-24
Language
English
PMID
23841892
DOI
10.3109/01480545.2013.806527
Web of Science Id
WOS:000327554900003
Abstract
Ethyl tertiary-butyl ether (ETBE) is commonly used as an oxygenated gasoline additive. In this study, we evaluated its developmental toxicity in rats. ETBE was administered by gavage to 21 or 22 pregnant female Sprague-Dawley rats per group at dose levels of 0, 100, 300 and 1000 mg/kg/day from days 5 through 19 postcoitum to assess its effects on pregnant animals and their embryos and fetuses applied to the OECD testing guideline (no. 414) correspondingly. There were no toxicological effects attributable to ETBE regarding clinical signs, body weight, food intake, necropsy or examination at caesarean section in pregnant animals. There were also no toxicological effects on external, visceral and skeletal examinations of embryos and fetuses. These results indicate that, under the conditions of this study, ETBE had no toxicological effects on pregnant rats or their embryos and fetuses and that the no observed adverse effect level was 1000 mg/kg/day both for pregnant rats and their embryos and fetuses.
Tags
IRIS
•
ETBE
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Combined Dataset (After duplicates removed electronically)
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Animal studies
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