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HERO ID
2325574
Reference Type
Journal Article
Title
Gas--liquid chromatographic resolution and assay of tocainide enantiomers using a chiral capillary column and study of their selective disposition in man
Author(s)
Mcerlane, KM; Pillai, GK
Year
1983
Is Peer Reviewed?
1
Journal
Journal of Chromatography
ISSN:
0021-9673
Volume
274
Issue
C
Page Numbers
129-138
Language
English
PMID
6409913
DOI
10.1016/s0378-4347(00)84416-3
Abstract
Tocainide is a new antiarrhythmic agent that is used clinically as the racemic mixture. In order to study the disposition of the individual enantiomers in man, a gas--liquid chromatographic assay was developed based on the resolution of the R-(-)- and S-(+)-enantiomers as their heptafluorobutyryl derivatives on a capillary column coated with a chiral stationary phase. Two healthy male volunteers ingested an oral solution dose of racemic tocainide hydrochloride at a dose of 3 mg/kg and plasma and urine were collected at intervals for up to 54 h. Analysis of the plasma samples revealed a stereoselective disappearance of the R-(-)-enantiomer, such that the apparent half-life for the S-(+)- and R-(-)-enantiomers were 25.6 and 20.5 h, respectively in one subject and 11.1 and 9.0 h in the second subject. Similar relationships were observed in urine, where the ratio of the S-(+)- to R-(-)-enantiomers varied from 0.98 in 1 h to 3.03 in the 54-h samples in one subject over the same time period.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFBA (375-22-4)
Literature Search
Pubmed
•
PFAS 150
Literature Search August 2019
PubMed
Perfluorobutanoic acid
•
PFBA
Literature Search
Pubmed
Screening Results
Excluded/Not on Topic
Protocol References
Scopus: April 2021
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