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HERO ID
2342685
Reference Type
Journal Article
Title
Validity of a questionnaire-based diagnosis of chronic obstructive pulmonary disease in a general population-based study
Author(s)
Murgia, N; Brisman, J; Claesson, A; Muzi, G; Olin, AC; Torén, K
Year
2014
Is Peer Reviewed?
Yes
Journal
BMC Pulmonary Medicine
ISSN:
1471-2466
Volume
14
Page Numbers
49
Language
English
PMID
24650114
DOI
10.1186/1471-2466-14-49
Web of Science Id
WOS:000335359800002
Abstract
BACKGROUND:
The diagnosis of chronic obstructive pulmonary disease (COPD) is based on airflow obstruction. In epidemiological studies, spirometric data have often been lacking and researchers have had to rely almost solely on questionnaire answers. The aim of this study is to assess the diagnostic accuracy of questionnaire answers to detect COPD.
METHODS:
A sample of the Swedish general population without physician-diagnosed asthma was randomly selected and interviewed using a respiratory questionnaire. All eligible subjects aged 25-75 years (n = 3892) performed spirometry for detection of airflow obstruction using Global Initiative for Chronic Obstructive Lung Disease (GOLD) or American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria. Sensitivity, specificity, positive likelihood ratio (LR+), positive predictive values (PPVs), and negative predictive values (NPVs) were calculated to define diagnostic accuracy of questionnaire answers.
RESULTS:
The sensitivity of the question "Have you been diagnosed by a physician as having COPD or emphysema?" in detecting airflow obstruction was 5.7% using GOLD, and 9.8% using ATS/ERS, criteria; specificity was 99.7% for GOLD and 99.5% for ATS/ERS. Sensitivity, specificity, and PPV were higher for the question compared to self-reported symptoms of chronic bronchitis in identifying subjects with airflow obstruction.
CONCLUSIONS:
The high specificity and good PPV suggest that the question "Have you been diagnosed by a physician as having COPD or emphysema?" is more likely to identify those who do not have airflow obstruction, whereas the low sensitivity of this question could underestimate the real burden of COPD in the general population.
Keywords
Airway obstruction; Spirometry; Sensitivity; Accuracy; ATS/ERS; GOLD
Tags
NAAQS
•
ISA - Lead (2024 Final Project Page)
Included in External Review Draft
Appendix 12 (Process)
•
ISA-NOx (2016)
Cited
2nd Draft
Final
Final Cited
•
ISA-Ozone (2020 Final Project Page)
Full-Text Screening Included
References from Other Sources
Included in ISA First Draft
Appendix 3
Appendix 4
Appendix 5
Appendix 6
Appendix 7
Included in ISA Final Draft
Appendix 3
Appendix 4
Appendix 5
Appendix 6
Appendix 7
•
ISA-PM (2019)
1st Draft
P-ES-A
Final ISA
P-ES-A
•
ISA-SOx
Considered
Cited in First ERD Nov2015
Cited Second ERD Dec2016
Cited in Final ISA Dec2017
Chapter 5 – Health
•
LitSearch-NOx (2024)
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Epidemiology
March 2014-November 2016
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Toxicology
March 2014-November 2016
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