Health & Environmental Research Online (HERO)


Print Feedback Export to File
2344743 
Journal Article 
Review 
An introduction to the molecular basics of aryl hydrocarbon receptor biology 
Abel, J; Haarmann-Stemmann, T 
2010 
Yes 
Biological Chemistry
ISSN: 1431-6730
EISSN: 1437-4315 
391 
11 
1235-1248 
English 
20868221 
Depending on their chemical structure and properties, environmental chemicals and other xenobiotics that enter the cell can affect cellular function by either nonselective binding to cellular macromolecules or by interference with cellular receptors, which would initiate a more defined cell biological response. One of these intracellular chemosensor molecules is the aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family that is known to mediate the biochemical and toxic effects of dioxins, polyaromatic hydrocarbons and related compounds. Numerous investigations have revealed that the AhR is not only a master regulator of drug metabolism activated by anthropogenic chemicals, but is also triggered by natural and endogenous ligands and can influence cell biological endpoints such as growth and differentiation. Cutting-edge research has identified new intriguing functions of the AhR, such as during proteasomal degradation of steroid hormone receptors, the cellular UVB stress response and the differentiation of certain T-cell subsets. In this review we provide both a survey of the fundamental basics of AhR biology and an insight into new functional aspects of AhR signaling to further stimulate research on this intriguing transcription factor at the interface between toxicology, cell biology and immunology. 
aryl hydrocarbon receptor; cytochrome P450; dioxin; transcription factor; xenobiotic metabolism 
IRIS
• Benzo(a)pyrene (BaP)