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Citation
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HERO ID
2345931
Reference Type
Journal Article
Title
Assessment of chemical coexposure patterns based upon phthalate biomonitoring data within the 2007/2008 National Health and Nutrition Examination Survey
Author(s)
Qian, H; Chen, M; Kransler, KM; Zaleski, RT
Year
2015
Is Peer Reviewed?
1
Journal
Journal of Exposure Science & Environmental Epidemiology
ISSN:
1559-0631
EISSN:
1559-064X
Publisher
NATURE PUBLISHING GROUP
Location
NEW YORK
Volume
25
Issue
3
Page Numbers
249-255
Language
English
PMID
24756100
DOI
10.1038/jes.2014.24
Web of Science Id
WOS:000353405500003
URL
http://
://WOS:000353405500003
Exit
Abstract
As regulatory initiatives increasingly call for an understanding of the cumulative risks from chemical mixtures, evaluating exposure data from large biomonitoring programs, which may inform these cumulative risk assessments, will improve the understanding of occurrence and patterns of coexposures. Here we have analyzed the urinary metabolite data for six phthalates (di-butyl phthalate; di-isobutyl phthalate; butyl-benzyl phthalate; bis(2-ethylhexyl) phthalate; di-isononyl phthalate; and di-isodecyl phthalate) in the 2007/2008 National Health and Nutrition Examination Survey (NHANES) data set. For the total data set (N=2604), the co-occurrence of multiple phthalates at the upper percentile of exposure was infrequent. There were no individuals in the NHANES sample who were exposed to >95th percentiles for all six phthalates. For 75% of individuals, none of the six phthalates were above the 95th percentile of their respective exposure distributions. These data suggest that high exposure to multiple phthalates is infrequent in the NHANES population. This analysis solely focused on the pattern of contribution of individual phthalates to total exposure. It did not address the pattern of contribution to potential risk. The approach presented could potentially be used to provide insight into understanding the coexposure patterns for other chemicals.Journal of Exposure Science and Environmental Epidemiology advance online publication, 23 April 2014; doi:10.1038/jes.2014.24.
Keywords
coexposure; phthalate; NHANES; biomonitoring
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
Literature Search
Litsearch April 2014 - February 2015
Pubmed
Litsearch March 2015 - June 2015
Pubmed
WOS
Additional Search Strategies
Excluded: No Primary Data on Health Effects
Exposure levels
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jul 2016 - Jan 2017
Considered new
WoS
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
September 2014 update
PubMed
New for this search
June 2015 Update
Web of Science
December 2015 Update
Web of Science
June 2016 Update
Toxline
Web of Science
January 2017 Update
Additional Search Strategies
No Primary Data on Toxic Effects
Exposure levels
Cited in September 2014 DIBP Preliminary Materials
•
Diisononyl Phthalate (DINP)
Literature Search
LitSearch Jan 2014 - July 2014
PubMed
Excluded: No Primary Data on Health Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - Jun 2014 Update (Private)
Pubmed
Source – Dec 2015 Update (Private)
WOS
Source - Jun 2016 Update (Private)
Pubmed
WOS
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