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HERO ID
2346004
Reference Type
Journal Article
Subtype
Review
Title
Integrative rodent models for assessing male reproductive toxicity of environmental endocrine active substances
Author(s)
Auger, J; Eustache, F; Rouiller-Fabre, V; Canivenc-Lavier, MC; Livera, G
Year
2014
Is Peer Reviewed?
Yes
Journal
Asian Journal of Andrology
ISSN:
1008-682X
EISSN:
1745-7262
Volume
16
Issue
1
Page Numbers
60-70
Language
English
PMID
24369134
DOI
10.4103/1008-682X.122366
Web of Science Id
WOS:000329409700008
Abstract
In the present review, we first summarize the main benefits, limitations and pitfalls of conventional in vivo approaches to assessing male reproductive structures and functions in rodents in cases of endocrine active substance (EAS) exposure from the postulate that they may provide data that can be extrapolated to humans. Then, we briefly present some integrated approaches in rodents we have recently developed at the organism level. We particularly focus on the possible effects and modes of action (MOA) of these substances at low doses and in mixtures, real-life conditions and at the organ level, deciphering the precise effects and MOA on the fetal testis. It can be considered that the in vivo experimental EAS exposure of rodents remains the first choice for studies and is a necessary tool (together with the epidemiological approach) for understanding the reproductive effects and MOA of EASs, provided the pitfalls and limitations of the rodent models are known and considered. We also provide some evidence that classical rodent models may be refined for studying the multiple consequences of EAS exposure, not only on the reproductive axis but also on various hormonally regulated organs and tissues, among which several are implicated in the complex process of mammalian reproduction. Such models constitute an interesting way of approaching human exposure conditions. Finally, we show that organotypic culture models are powerful complementary tools, especially when focusing on the MOA. All these approaches have contributed in a combinatorial manner to a better understanding of the impact of EAS exposure on human reproduction.
Keywords
endocrine active substance; endocrine disruptor; exposure; gonad in culture; low dose; mixture; mouse; rat; rodent; strain
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
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WOS
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Source - Jun 2014 Update (Private)
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Source – Dec 2014 Update (Private)
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Source – Mar 2015 Update (Private)
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