US EPA

2346031 

Journal Article 

Flow Injection Potentiometric Determination of Terazosin Hydrochloride Using Modified Carbon Paste Electrodes 

Zayed, SIM; Khalil, MM; Issa, YM; Khalefa, HR 

2014 

Yes 

International Journal of Electrochemical Science
ISSN: 1452-3981 

9 

5 

2327-2340 

WOS:000334492800011 

Three carbon paste electrodes for determination of terazosin hydrochloride (TerazCl) were prepared based on ion association complexes with sodium tetraphenylborate (NaTPB), ammonium reineckate and phosphotungstic acid (PTA), using dibutyl phthalate as solvent mediator. The developed sensors showed a near-Nernstian response over the concentration range 3.98x10(-5)-1.00x10(-2) mol L-1 TerazCl with detection limits of 2.18x10(-5), 3.60x10(-5) and 1.26x10(-5) mol L-1 TerazCl, in case of tetraphenylborate, reineckate, and phosphotungstate, respectively. The proposed sensors exhibit good selectivity for terazosin with respect to a large number of inorganic cations, sugars, amino acids and vitamins. The sensors were successfully applied for the potentiometric determination of TerazCl in pharmaceutical preparation in batch and flow injection conditions. The sensors were also applied for the determination of TerazCl in spiked human urine samples by using the standard addition method. 

Terazosin hydrochloride; modified carbon paste electrodes; flow injection analysis; potentiometry