US EPA

2349573 

Journal Article 

Prenatal exposures to perfluorinated chemicals and anthropometry at 7 years of age 

Andersen, CS; Fei, C; Gamborg, M; Nohr, EA; Sørensen, TI; Olsen, J 

2013 

Yes 

American Journal of Epidemiology
ISSN: 0002-9262
EISSN: 1476-6256 

OXFORD UNIV PRESS INC 

CARY 

178 

6 

921-927 

English 

23825166 

10.1093/aje/kwt057 

WOS:000325150600014 

Fetal exposure to the perfluoroalkyl acids, perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), has been associated with lower birth weight and lower weight and body mass index (weight (kg)/height (m)(2)) in early infancy. It is, however, unclear if exposure to prenatal PFOS and PFOA has a lasting influence on growth. We estimated the associations between the maternal plasma level of PFOS or PFOA and the children's body mass index, waist circumference, and risk of overweight at 7 years of age. A total of 1,400 women were randomly selected from the Danish National Birth Cohort among those who provided blood samples early in pregnancy and gave birth to liveborn singletons in 1996-2002. Weight and height information at 7 years was available for 811 children. Multiple linear and logistic regression models were used for analyses. Maternal PFOS and PFOA concentrations were overall inversely but nonsignificantly associated with the children's body mass index, waist circumference, and risk of overweight at 7 years of age. In conclusion, plasma levels of PFOS and PFOA in pregnant women did not seem to have any appreciable influence on their children's anthropometry at this point in childhood. 

Prenatal development; Human exposure; Chemicals; Epidemiology; 2013)