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Journal Article 
Respiratory clearance of aerosolized radioactive solutes of varying molecular weight 
Huchon, GJ; Montgomery, AB; Lipavsky, A; Hoeffel, JM; Murray, JF 
Journal of Nuclear Medicine
ISSN: 0161-5505
EISSN: 1535-5667 
To determine the influence of varying molecular weight (mol wt) on respiratory clearance of aerosolized salutes, we studied eight radiopharmaceuticals, each administered to four dogs: sodium 99MTc pertechnetate (TcO4),99MTc glucoheptonate ([99M'Tc]GH), 51Cr-ethylenedinitrotetraacetate ([51Cr]EDTA), 99mTc diethylenetriaminepentaacetate ([99mTc] DTPA), 111In diethylenetriaminepentaacetate ([111In]DTPA), 67Ga desferoxaminemesylate ([67Ga]DFOM) 99mTc dextran ([99mTc]DX) and 111In transferrin ([1 11InJTF) After aerosolization (0.8 m MMD, 2.4 GSD), clearance was determined for 30 mm and then corrected by intravenous injection for nonairspace radioactivity. In-TF clearance (-0.11 ± 0.10 %/min) was lower than TcO4 (6.32 ± 0.62 %/min), [99mTc]GH (1.50 ± 0.37 0/o/min), [51Cr]EDTA (2.38 ± 1.02 %/min), [99mTc]DTPA (3.51 ± 0.40 %/min), [111In]DTPA (2.35 ± 0.42 %/min), [67Ga] DFOM (1.99 ± 0.49 %/min) and (99mTc]DX (1.81 ± 0.75 %/min) clearances (p < 0.001). TcO4 clearance was higher than others (p < 0.001). Technetium binding to DX was unsatisfactory; aerosolization caused unbinding from DTPA. We conclude that respiratory clearance of large mol wt salutes within 30 mm is negligible and, that clearance of molecules between 347-5,099 daltons differs greatly, suggesting that binding and/or intrapulmonary retention affect transfer. 
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