Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2530089

Reference Type

Journal Article

Title

Final report on the safety assessment of PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate

Author(s)

Robinson, V; Bergfeld, WF; Belsito, DV; Klaassen, CD; Marks, JG; Shank, RC; Slaga, TJ; Snyder, PW; Cosmetic Ingredient Review Expert Panel; Andersen, FA

Year

2009

Is Peer Reviewed?

Journal

International Journal of Toxicology
ISSN: 1091-5818
EISSN: 1092-874X

Volume

Issue

6 Suppl

Page Numbers

162S-74S

Language

English

PMID

19966148

DOI

10.1177/1091581809350933

Web of Science Id

WOS:000272523600002

Abstract

PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are used in cosmetics as fragrance ingredients and/or solvents at concentrations of 0.4% to 2%. Propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure, but the inhalation toxicity of PPG-2 methyl ether vapor, for example, is low. Aerosols, such as found with hair sprays, produce particle sizes that are not respirable. Because these ingredients are highly water-soluble, they are likely to be absorbed through the human skin only at slow rates, resulting in low blood concentrations and rapid removal by the kidney. These ingredients are not genotoxic and are not reproductive or developmental toxicants. Overall the data are sufficient to conclude that PPG-2 methyl ether, PPG-3 methyl ether, and PPG-2 methyl ether acetate are safe as used in cosmetics.

Keywords

PPG-2 methyl ether; PPG-3 methyl ether; PPG-2 methyl ether acetate; cosmetics; safety