US EPA

2677591 

Journal Article 

Evaluation of Efficacy of Oral Administration of Bordetella bronchiseptica Intranasal Vaccine When Used to Protect Puppies from Tracheobronchitis Due to B bronchiseptica Infection 

Hess, TJ; Parker, DS; Hassall, AJ; Chiang, YuWei 

2011 

9 

3 

300-305 

WOS:000296122000010 

This study evaluated the efficacy of oral administration of two Bordetella bronchiseptica vaccines(a,b) regarding prevention of canine infectious tracheobronchitis (ITB). Puppies free of B bronchiseptica by culture and serological testing were used in this study. At 8 weeks of age the puppies were randomly distributed into three groups. Group A received the placebo vaccine. Group B received the multivalent vaccine.a Group C received the monovalent vaccine.b The puppies were orally immunized with a single dose of vaccine in the buccal pouch. Five weeks after vaccination, they were challenged with virulent B bronchiseptica using an aerosol challenge model. They were observed for 30 minutes twice daily for 14 days. After challenge none of the multivalent-vaccinated puppies, only 1 of the monovalent-vaccinated puppies, and all of the placebo-vaccinated puppies had tracheobronchitis. Results of this study demonstrate excellent efficacy for prevention of ITB due to B bronchiseptica infection for these orally administered vaccines containing avirulent live B bronchiseptica. 

Bordetella bronchiseptica vaccines; canine infectious tracheobronchitis; injectable or intranasal administration