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HERO ID
2718064
Reference Type
Journal Article
Title
Urinary phthalate metabolites and biomarkers of oxidative stress in pregnant women: A repeated measures analysis
Author(s)
Ferguson, KK; Mcelrath, TF; Chen, YH; Mukherjee, B; Meeker, JD
Year
2015
Is Peer Reviewed?
Yes
Journal
Environmental Health Perspectives
ISSN:
0091-6765
EISSN:
1552-9924
Publisher
Public Health Services, US Dept of Health and Human Services
Volume
123
Issue
3
Page Numbers
210-216
Language
English
PMID
25402001
DOI
10.1289/ehp.1307996
Web of Science Id
WOS:000352167900010
URL
https://search.proquest.com/docview/1668249549?accountid=171501
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Abstract
BACKGROUND:
Phthalate exposure occurs readily in the environment and has been associated with an array of health endpoints, including adverse birth outcomes. Some of these may be mediated by oxidative stress, a proposed mechanism for phthalate action.
OBJECTIVES:
In the present study we explore the associations between phthalate metabolites and biomarkers of oxidative stress measured in urine samples from multiple time points during pregnancy.
METHODS:
Women were participants in a nested case-control study of preterm birth (N=130 cases, N=352 controls). Each was recruited early in pregnancy and followed until delivery, providing urine samples at up to 4 visits. Nine phthalate metabolites were measured to assess exposure, and 8-hydroxydeoxyguanosine and 8-isoprostane were also measured in urine as markers of oxidative stress. Associations were assessed using linear mixed models to account for intra-individual correlation, with inverse selection probability weightings based on case status to allow for greater generalizability.
RESULTS:
Interquartile range increases in phthalate metabolites were associated with significantly higher concentrations of both biomarkers. Estimated differences were greater in association with mono-benzyl phthalate (MBzP), mono-n-butyl phthalate (MBP), and mono-iso-butyl phthalate (MiBP), compared with di-2-ethylhexyl (DEHP) metabolites.
CONCLUSIONS:
Urinary phthalate metabolites were associated with increased oxidative stress biomarkers in our study population of pregnant women. These relationships may be particularly relevant to the study of birth outcomes linked to phthalate exposure. Although replication is necessary in other populations, these results may also be of great importance for a range of other health outcomes associated with phthalates.
Keywords
Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Oxidative stress; Phthalic acid; biomarkers; Population studies; Phthalates; Pregnancy; Metabolites; 8-Hydroxydeoxyguanosine; Replication; Bioindicators; Internet; Females; ENA 02:Toxicology & Environmental Safety; X 24350:Industrial Chemicals; H 12000:Epidemiology and Public Health
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jul 2016 - Jan 2017
Considered new
WoS
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
June 2015 Update
Toxline
Web of Science
New for this Search
December 2015 Update
Web of Science
June 2016 Update
Toxline
Web of Science
January 2017 Update
Primary Source of Health Effects Studies
Human health effects studies
Studies with Supporting Data
Mechanistic and genotoxicity studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source – Dec 2014 Update (Private)
Pubmed
Source – Mar 2015 Update (Private)
Pubmed
Source – Dec 2015 Update (Private)
Pubmed
WOS
Source - Jun 2016 Update (Private)
Pubmed
WOS
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