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HERO ID
2718081
Reference Type
Journal Article
Title
The potential use of diisononyl phthalate metabolites hair as biomarkers to assess long-term exposure demonstrated by a rat model
Author(s)
Hsu, JY; Ho, HH; Liao, PC
Year
2015
Is Peer Reviewed?
Yes
Journal
Chemosphere
ISSN:
0045-6535
EISSN:
1879-1298
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
118
Issue
1
Page Numbers
219-228
Language
English
PMID
25278043
DOI
10.1016/j.chemosphere.2014.09.025
Web of Science Id
WOS:000346953700031
URL
https://linkinghub.elsevier.com/retrieve/pii/S0045653514010923
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Abstract
Diisononyl phthalate (DINP) is a widely used industrial plasticizer. People come into contact with this chemical by using plastic products made with it. Human health can be adversely affected by long-term DINP exposure. However, because the body rapidly excretes DINP metabolites, the use of single-point urine analysis to assess long-term exposure may produce inconsistent results in epidemiologic studies. Hair analysis has a useful place in biomonitoring, particularly in estimating long-term or historical exposure for some chemicals. Several studies have reported using hair analysis to assess the concentrations of heavy metals, drugs and organic pollutants in humans. As a biomarker, DINP metabolites were measured in rat hair in animal experiments to evaluated long-term exposure to DINP. In addition, we evaluated the correlation between the levels of DINP metabolites in hair and in urine. The levels of DINP metabolites in rat hair were significantly higher in the exposure group, relative to the control group (p<0.05). DINP metabolites had a positive correlation with increasing administered dose. Significant positive correlations for MINP, MOINP and MHINP were found between hair and urine (r=0.86, r=0.79 and r=0.74, respectively, p<0.05). Several metabolites in urine showed earlier saturation than in hair. In this report, we detected eight metabolites in hair and demonstrate that hair analysis has potential applications in the assessment of long-term exposure to DINP.
Keywords
Diisononyl phthalate; Metabolites; Long-term exposure; Hair; Biomarker
Tags
IRIS
•
Diisononyl Phthalate (DINP)
Literature Search
Excluded: No Primary Data on Health Effects
Measurement methods
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source – Dec 2014 Update (Private)
Pubmed
Source – Mar 2015 Update (Private)
WOS
Source – Dec 2015 Update (Private)
Pubmed
WOS
Source - Jun 2016 Update (Private)
WOS
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