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Citation
Tags
HERO ID
2718085
Reference Type
Journal Article
Title
Bisphenol A and phthalate metabolite urinary concentrations: Daily and across pregnancy variability
Author(s)
Fisher, M; Arbuckle, TE; Mallick, R; Leblanc, A; Hauser, R; Feeley, M; Koniecki, D; Ramsay, T; Provencher, G; Bérubé, R; Walker, M
Year
2015
Is Peer Reviewed?
1
Journal
Journal of Exposure Science & Environmental Epidemiology
ISSN:
1559-0631
EISSN:
1559-064X
Volume
25
Issue
3
Page Numbers
231-239
Language
English
PMID
25248937
DOI
10.1038/jes.2014.65
Web of Science Id
WOS:000353405500001
Abstract
Phthalates and bisphenol A (BPA) are high production volume and ubiquitous chemicals that are quickly metabolized in the body. Traditionally, studies have relied on single spot urine analyses to assess exposure; ignoring variability in concentrations throughout a day or over a longer period of time. We compared BPA and phthalate metabolite results from urine samples collected at five different time points. Participants (n=80) were asked to collect all voids in a 24 h period on a weekday and then again on a weekend before 20 weeks of pregnancy. During the second and third trimesters and in the postpartum period, single spot urines were collected. Variability over time in urinary concentrations was assessed using intraclass correlation coefficients (ICCs) and the sensitivity to correctly classify a single sample as high or low versus the geometric mean (GM) of all samples was calculated. We found low reproducibility and sensitivity of BPA and all phthalate metabolites throughout pregnancy and into the postpartum period but much higher reproducibility within a day. Time of day when the urine was collected was a significant predictor of specific gravity adjusted exposure levels. We concluded that, if the interest is in average exposures across pregnancy, maternal/fetal exposure estimation may be more accurate if multiple measurements, collected across the course of the entire pregnancy, rather than a single spot measure, are performed.Journal of Exposure Science and Environmental Epidemiology advance online publication, 24 September 2014; doi:10.1038/jes.2014.65.
Keywords
phthalates; bisphenol A; pregnancy; temporal variability; intraclass correlation
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source – Dec 2014 Update (Private)
Pubmed
Source – Dec 2015 Update (Private)
WOS
Source - Jun 2016 Update (Private)
Pubmed
WOS
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