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2756722 
Journal Article 
Antitumour activity of coumarin in prostate and mammary cancer models 
von Angerer, E; Kager, M; Maucher, A 
1994 
Yes 
Journal of Cancer Research and Clinical Oncology
ISSN: 0171-5216
EISSN: 1432-1335 
120 Suppl 
S14-S16 
English 
8132695 
The antineoplastic and antimetastatic activities of coumarin were evaluated in transplanted prostate tumours of the rat. The growth of Noble Nb-R prostate tumours was strongly inhibited by coumarin (40 mg/kg; administered three times per week), whereas the hormonally more sensitive Dunning R3327-G rat prostate carcinoma did not respond. Coumarin was also shown to possess antimetastatic activity in a Dunning R3327-MatLu tumour model. The number of lung metastases was reduced significantly by 40%-50% following the administration of coumarin (40 mg daily). Preliminary data from experiments with rats bearing DMBA-induced mammary carcinomas showed that these tumours are as sensitive to coumarin as Noble-R-prostate tumours.