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2810886 
Journal Article 
Review 
Childhood acute myeloid leukaemia 
Rubnitz, JE; Inaba, H 
2012 
Yes 
British Journal of Haematology
ISSN: 0007-1048
EISSN: 1365-2141 
159 
3 
259-276 
English 
22966788 
WOS:000309717500003 
Although acute myeloid leukaemia (AML) has long been recognized for its morphological and cytogenetic heterogeneity, recent high-resolution genomic profiling has demonstrated a complexity even greater than previously imagined. This complexity can be seen in the number and diversity of genetic alterations, epigenetic modifications, and characteristics of the leukaemic stem cells. The broad range of abnormalities across different AML subtypes suggests that improvements in clinical outcome will require the development of targeted therapies for each subtype of disease and the design of novel clinical trials to test these strategies. It is highly unlikely that further gains in long-term survival rates will be possible by mere intensification of conventional chemotherapy. In this review, we summarize recent studies that provide new insight into the genetics and biology of AML, discuss risk stratification and therapy for this disease, and profile some of the therapeutic agents currently under investigation. 
acute myeloid leukaemia; AML; childhood leukaemia