Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2822073
Reference Type
Journal Article
Title
Environmental factors and apoptotic indices in patients with intrauterine growth retardation: A nested case-control study
Author(s)
El-Baz, MA; El-Deeb, TS; El-Noweihi, AM; Mohany, KM; Shaaban, OM; Abbas, AM
Year
2015
Is Peer Reviewed?
Yes
Journal
Environmental Toxicology and Pharmacology
ISSN:
1382-6689
EISSN:
1872-7077
Volume
39
Issue
2
Page Numbers
589-596
Language
English
PMID
25682005
DOI
10.1016/j.etap.2015.01.009
Web of Science Id
WOS:000353929900012
Abstract
BACKGROUND:
Egypt has one of the highest incidences of IUGR. The current study investigates the effect of heavy metals toxicity as risk factors of IUGR and determines the possible role of increased apoptosis in their pathogenesis.
METHODS:
This study was conducted in Assiut, Egypt, included 60 women diagnosed to have IUGR. We measured lead and cadmium levels in blood besides arsenic and cadmium levels in urine. Neonatal scalp hair sample were analyzed for arsenic content. Quantitative determination of human placental Bcl-2 and caspase-3 were performed.
RESULTS:
There are significantly higher levels of heavy metals and caspase-3 and lower levels of placental Bcl-2 in the IUGR group. The levels of heavy metals were positively correlated with caspase-3 while negatively correlated (except cadmium) with Bcl-2 levels.
CONCLUSIONS:
There is an alarming high level of heavy metals toxicity in Egypt that was positively correlated to IUGR. Increased placental apoptosis may be one of the possible mechanisms behind the effect.
Keywords
IUGR; Lead; Cadmium; Arsenic; Apoptosis; Caspase-3
Tags
IRIS
•
Arsenic Hazard ID
Lit Search Updates Oct 2015 to Jan 2019
ToxNet
WOS
2.5 Update 2015-2019: Title & Abstract Screening
Not relevant to PECO
8. Hazard through Oct 2015
Epi Hazard ID
•
Arsenic (Inorganic)
3. Hazard ID Screening
Potentially relevant epidemiology studies
Cited in Volume 1
Cited in Volume 2a
Cited in Volume 2b
NAAQS
•
ISA - Lead (2024 Final Project Page)
Title-Abstract Screening (SWIFT-AS) - Included
Title-Abstract Screening (SWIFT-AS) - Included
Full-Text Screening Included
Full-Text Screening Included
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity