US EPA

2849830 

Journal Article 

Promotion or suppression of glucose isomerization in subcritical aqueous straight- and branched-chain alcohols 

Gao, DM; Kobayashi, T; Adachi, S 

2015 

Yes 

Bioscience, Biotechnology, and Biochemistry
ISSN: 0916-8451
EISSN: 1347-6947 

79 

3 

470-474 

English 

25345422 

10.1080/09168451.2014.973366 

WOS:000350470400016 

The influence of water-miscible alcohols (methanol, 1-propanol, 2-propanol, and t-butyl alcohol) on the isomerization of glucose to fructose and mannose was investigated under subcritical aqueous conditions (180-200 °C). Primary and secondary alcohols promoted the conversion and isomerization of glucose to afford fructose and mannose with high and low selectivity, respectively. On the other hand, the decomposition (side-reaction) of glucose was suppressed in the presence of the primary and secondary alcohols compared with that in subcritical water. The yield of fructose increased with increasing concentration of the primary and secondary alcohols, and the species of the primary and secondary alcohols tested had little effect on the isomerization behavior of glucose. In contrast, the isomerization of glucose was suppressed in subcritical aqueous t-butyl alcohol. Both the conversion of glucose and the yield of fructose decreased with increasing concentration of t-butyl alcohol. In addition, mannose was not detected in reactions using subcritical aqueous t-butyl alcohol. 

subcritical aqueous ethanol; glucose; mannose; fructose; isomerization