Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2850295
Reference Type
Journal Article
Title
Toxicokinetics of ammonium perfluorohexanoate
Author(s)
Iwai, H
Year
2011
Is Peer Reviewed?
Yes
Journal
Drug and Chemical Toxicology
ISSN:
0148-0545
EISSN:
1525-6014
Volume
34
Issue
4
Page Numbers
341-346
Language
English
PMID
21696261
DOI
10.3109/01480545.2011.585162
Web of Science Id
WOS:000294861800001
Abstract
Excretion patterns and rates of ammonium perfluorohexanoate (APFHx) after administration of a single and multiple (14 days) oral dose(s) at 50 mg/kg to male and female mice and rats were examined. The test substance was [(14)C]-labeled APFHx. After a single oral administration, total excretion was rapid, with mean recoveries of over 90% of the dose at 24 hours after administration, irrespective of gender or species. The major route of elimination was via the urine (means of percentage recovery between 73.0 and 90.2% of the dose), followed by the feces (means of percentage recovery between 7.0 and 15.5% of the dose). Elimination via expired air was negligible. For the multiple dose tests, multiple (13 daily doses) oral administration of APFHx was followed by a single oral administration of [(14)C]-APFHx. Excretion was rapid, with mean recoveries of over 90% of the administered dose (mean values >95% of the ultimately recovered material) at 24 hours after dosing, irrespective of gender or species. The major route of elimination was via the urine (means of percentage recovery between 77.8 and 83.4% of the dose), followed by the feces (means of percentage recovery between 9.6 and 12.9% of the dose).
Keywords
Ammonium perfluorohexanoate; APFHx; C6; Toxicokinetics
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFHxA (307-24-4)
Literature Search
Pubmed
WOS
•
PFAS 150
Literature Search Update December 2020
PubMed
Literature Search August 2019
PubMed
Screened Studies
Excluded
Exclude (TIAB)
Perfluorohexanoic acid
•
PFBA
Protocol References
•
PFHxA
Literature Search
Pubmed
WOS
LitSearch Update: February 2018
Term Set 2: Initial Search
PubMed
WoS
Literature Search
Pubmed
WOS
Scopus: April 2021
Screening Results
Excluded/Not on Topic
Title and Abstract Screening
Full Text Screening
Studies Meeting PECO
ADME TK
Tagged as Supplemental
ADME TK
HAWC
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity