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HERO ID
2850314
Reference Type
Journal Article
Title
Absorption, distribution, metabolism, and excretion of [1-¹⁴C]-perfluorohexanoate ([¹⁴C]-PFHx) in rats and mice
Author(s)
Gannon, SA; Johnson, T; Nabb, DL; Serex, TL; Buck, RC; Loveless, SE
Year
2011
Is Peer Reviewed?
1
Journal
Toxicology
ISSN:
0300-483X
EISSN:
1879-3185
Volume
283
Issue
1
Page Numbers
55-62
Language
English
PMID
21349313
DOI
10.1016/j.tox.2011.02.004
Web of Science Id
WOS:000290053000008
Abstract
The absorption, tissue distribution, elimination, and metabolism of [1-¹⁴C]-PFHx in rats and mice dosed orally at 2 or 100 mg/kg was evaluated following a single dose or after 14 consecutive doses. Absorption was rapid in rats as evidenced by a short time to maximum concentration (C(max)) of 30 min in male rats and 15 min in female rats at both the 2 and 100mg/kg dose level. The plasma elimination half-life was somewhat longer in males (1.5-1.7 h) than in females (0.5-0.7 h). Absorption in the mouse was also rapid with the maximum plasma concentration occurring between 15 and 30 min after dosing. The maximum concentration was not appreciably different between male and female mice (8 μg equiv./g at 2 mg/kg; ~350 μg equiv./g at 100 mg/kg). The primary route of elimination was via the urine. PFHx was not metabolized in rat or mouse hepatocytes, nor were any metabolites observed after oral dosing in either rodent species. Essentially 100% of the dose was eliminated in urine within 24 h demonstrating that PFHx is readily absorbed and bioavailability approaches 100%, even at a dose as high as 100 mg/kg. The route and extent of elimination was unchanged after 14 days of daily dosing. Tissues were collected at three time points (rat: 0.5, 2, and 24 h; mice: 0.25, 1, and 24 h) after dosing to investigate the tissue clearance kinetics of PFHx following a single dose at 2 or 100 mg/kg. In all tissues except skin, PFHx was not quantifiable 24 h after dosing in both sexes of the two species.
Keywords
Perfluorohexanoate; ADME; Perfluoroalkyl; Tissue distribution
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFHxA (307-24-4)
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PFAS 150
Literature Search Update December 2020
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Ammonium perfluorooctanoate
Perfluorohexanoic acid
•
PFBA
Protocol References
•
PFHxA
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Term Set 2: Initial Search
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Toxicokinetic studies
ADME
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Studies Meeting PECO
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HAWC
•
PFHxS
•
Yale PFAS Liver study
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