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HERO ID
2854656
Reference Type
Journal Article
Title
Cardiovascular disease and arsenic exposure in Inner Mongolia, China: a case control study
Author(s)
Wade, TJ; Xia, Y; Mumford, J; Wu, K; Le, XC; Sams, E; Sanders, WE
Year
2015
Is Peer Reviewed?
1
Journal
Environmental Health
EISSN:
1476-069X
Volume
14
Issue
1
Page Numbers
35
Language
English
PMID
25889926
DOI
10.1186/s12940-015-0022-y
Web of Science Id
WOS:000353374300001
Abstract
BACKGROUND:
Millions of people are at risk from the adverse effects of arsenic exposure through drinking water. Increasingly, non-cancer effects such as cardiovascular disease have been associated with drinking water arsenic exposures. However, most studies have been conducted in highly exposed populations and lacked individual measurements.
OBJECTIVE:
To evaluate the association between cardiovascular disease and well-water arsenic exposure.
METHODS:
We conducted a hospital based case control study in Inner Mongolia, China. Cases and controls were prospectively identified and enrolled from a large hospital in the Hangjin Hou area. Cases were patients diagnosed with cardiovascular disease and controls were patients free from cardiovascular disease, admitted for conditions unrelated to arsenic exposure. Water from the primary water source and toenail samples were collected from each subject and tested for inorganic arsenic.
RESULTS:
Arsenic exposures were moderate with mean and median arsenic exposures of 8.9 μg/L and 13.1 μg/L, respectively. A total of 298 cases and 275 controls were enrolled. The adjusted odds ratio (AOR) and corresponding 95% confidence interval (95% CI) for a 10 μg/L increase in water arsenic were 1.19 (95% CI: 1.03, 1.38). Compared to exposures less than 10 μg/L, the AOR for water arsenic exposures above 40 μg/L was 4.05 (95% CI: 1.1-14.99, p = 0.04). Nail arsenic above 1.38 μg/g was also associated with an increased risk of cardiovascular disease.
CONCLUSIONS:
By using standardized case definitions and collecting individual measurements of arsenic, this study addressed several limitations of previous studies. The results provide further evidence of the association between cardiovascular disease and arsenic at moderate exposures.
Keywords
Arsenic; Cardiovascular disease; China; Drinking water
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IRIS
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Arsenic Hazard ID
Lit Search Updates Oct 2015 to Jan 2019
ToxNet
WOS
2.5 Update 2015-2019: Title & Abstract Screening
Considered for further screening
8. Hazard through Oct 2015
Epi Hazard ID
9. Hazard ID through Oct. 2015_Epi 2019 PECO
Circulatory System effects
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Arsenic (Inorganic)
3. Hazard ID Screening
Potentially relevant epidemiology studies
Cited in Volume 1
Cited in Volume 2a
Cited in Volume 2b
•
Arsenic Susceptibility
Life Stages Citation Mapping
20%-25%
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