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2919386 
Journal Article 
Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006 
Olsen, GW; Mair, DC; Church, TR; Ellefson, ME; Reagen, WK; Boyd, TM; Herron, RM; Medhdizadehkashi, Z; Nobiletti, JB; Rios, JA; Butenhoff, JL; Zobel, LR 
2008 
Yes 
Environmental Science and Technology
ISSN: 0013-936X
EISSN: 1520-5851 
42 
13 
4989-4995 
English 
In 2000, 3M Company, the primary global manufacturer, announced a phase-out of perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F)-based materials after perfluorooctanesulfonate (PFOS, C8F17SO3-) was reported in human populations and wildlife. The purpose of this study was to determine whether PFOS and other polyfluoroalkyl concentrations in plasma samples, collected in 2006 from six American Red Cross adult blood donor centers, have declined compared to nonpaired serum samples from the same locations in 2000-2001. For each location, 100 samples were obtained evenly distributed by age (20-69 years) and sex. Analytes measured, using tandem mass spectrometry, were PFOS, perfluorooctanoate (PFOA), perfluorohexanesulfonate (PFHxS), perfluorobutanesulfonate (PFBS), N-methyl perfluorooctanesulfonamidoacetate (Me-PFOSA-AcOH), and N-ethyl perfluorooctanesulfonamidoacetate (Et-PFOSA-AcOH). The geometric mean plasma concentrations were for PFOS 14.5 ng/mL (95% CI 13.9-15.2), PFOA 3.4 ng/ mL (95% CI 3.3-3.6), and PFHxS 1.5 ng/mL (95% CI 1.4-1.6). The majority of PFBS, Me-PFOSA-AcOH, and Et-PFOSA-AcOH concentrations were less than the lower limit of quantitation. Age- and sex-adjusted geometric means were lower in 2006 (approximately 60% for PFOS, 25% for PFOA, and 30% for PFHxS) than those in 2000-2001. The declines for PFOS and PFHxS are consistent with their serum elimination half-lives and the time since the phase-out of POSF-based materials. The shorter serum elimination half-life for PFOA and its smaller percentage decline than PFOS suggests PFOA concentrations measured in the general population are unlikely to be solely attributed to POSF-based materials. Direct and indirect exposure sources of PFOA could include historic and ongoing electrochemical cell fluorination (ECF) of PFOA, telomer production of PFOA, fluorotelomer-based precursors, and other fluoropoly-mer production. 
• NEtFOSAA
     Literature Search
          Pubmed
          WOS
     Screening Results
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• NMeFOSAA
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• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFBS (375-73-5)
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               Pubmed
               WOS
     PFHxS (355-46-4)
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               Pubmed
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     PFOSA (754-91-6)
          Literature Search
               Pubmed
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     NEtFOSAA (2991-50-6)
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               Pubmed
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     NMeFOSAA (2355-31-9)
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• PFBS
          Pubmed
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          PubMed
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     Excluded
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• PFHxS
     Literature Search
          PubMed
          Toxline
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     Screening Results
          Excluded/Not on Topic
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• PFOSA
     Literature Search
          Pubmed
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