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Citation
Tags
HERO ID
29216
Reference Type
Journal Article
Title
Learning impairment in mice following acute exposure to dichloromethane and carbon tetrachloride
Author(s)
Alexeeff, GV; Kilgore, WW
Year
1983
Is Peer Reviewed?
1
Journal
Journal of Toxicology and Environmental Health
ISSN:
0098-4108
Book Title
J. Toxicol. Environ. Health
Volume
11
Issue
4-6
Page Numbers
569-581
Language
English
PMID
6620402
DOI
10.1080/15287398309530368
Web of Science Id
WOS:A1983RH88700007
Abstract
Mice were exposed via inhalation to high concentrations of either dichloromethane (168 mg/l) or carbon tetrachloride (134.3 mg/l). The mice were tested for learning ability using a passive-avoidance conditioning task. Exposed animals were found to have a significantly decreased ability to learn when compared with controls. The 3-wk-old mice were more affected than the 5-wk-old and the 8-wk-old mice. The exposed animals were indistinguishable from controls in terms of motor activity, weight gain, and absence of analgesia.
Tags
•
DCM (Dichloromethane) (Final, 2011)
OPPT REs
•
OPPT_Carbon Tetrachloride_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Carbon Tetrachloride_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Carbon Tetrachloride_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Animal hazard ID
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