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Citation
Tags
HERO ID
29217
Reference Type
Journal Article
Title
Cytogenetic analyses of mice exposed to dichloromethane
Author(s)
Allen, J; Kligerman, A; Campbell, J; Westbrook-Collins, B; Erexson, G; Kari, F; Zeiger, E
Year
1990
Is Peer Reviewed?
Yes
Journal
Environmental and Molecular Mutagenesis
ISSN:
0893-6692
EISSN:
1098-2280
Volume
15
Issue
4
Page Numbers
221-228
Language
English
PMID
2357975
DOI
10.1002/em.2850150409
Web of Science Id
WOS:A1990DL42300008
Abstract
Chromosome damage was studied in female B6C3F1 mice exposed to dichloromethane (DCM) by subcutaneous or inhalation treatments. No increase in the frequency of either sister chromatid exchanges (SCEs) or chromosome aberrations (CAs) in bone marrow cells was observed after a single subcutaneous injection of 2,500 or 5,000 mg/kg DCM. Inhalation exposure to DCM for 10 days at concentrations of 4,000 or 8,000 ppm resulted in significant increases in frequencies of SCEs in lung cells and peripheral blood lymphocytes, CAs in lung and bone marrow cells, and micronuclei (MN) in peripheral blood erythrocytes. Lung cell CAs and blood erythrocyte MN reached frequencies of approximately two times control levels. Following a 3-month inhalation exposure to 2,000 ppm DCM, mice showed small but significant increases in lung cell SCEs and peripheral blood erythrocyte MN. These findings suggest that genotoxicity may play a role in the carcinogenicity of DCM in the lungs of B6C3F1 female mice.
Tags
IRIS
•
DCM (Dichloromethane) (Final, 2011)
OPPT REs
•
OPPT_Methylene Chloride_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Methylene Chloride_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
MOA
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