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2942970 
Journal Article 
Assessment of the dermal bioavailability of soil-aged benzo(a)pyrene 
Abdel-Rahman, MS; Skowronski, GA; Turkall, RM 
2002 
Yes 
Human and Ecological Risk Assessment
ISSN: 1080-7039
EISSN: 1549-7860 
TAYLOR & FRANCIS INC 
PHILADELPHIA 
8 
2 
429-441 
English 
WOS:000174218600015 
Exposure to polycyclic aromatic hydrocarbons (PAHs) in soil is a major health concern because of their mutagenic and carcinogenic properties. The aim of this research was to determine the dermal bioavailability of benzo(a)pyrene (BaP) aged in either a sandy or a clay soil in order to assess the health risks and remediation goals for the chemical. In vitro flow-through diffusion cell studies were conducted utilizing dermatomed male pig skin. The amount of radioactive chemical was measured that penetrated skin into receptor fluid and which was bound to skin following soap and water decontamination. BaP bioavailability was decreased by 95 to 98% after 3 months of aging in soil relative to the pure compound. Less than 0.3% of the dose was detected in receptor fluid for all treatments. While most of the dose was bound to skin after administering the pure compound, the majority of the radioactivity was found in the soil and decontaminate after aging. The results indicate that the health risk from exposure to BaP is significantly reduced as the compound ages in soil and that less soil cleanup would be needed at sites contaminated with aged BaP. © 2002 by ASP. 
polyaromatic hydrocarbon; skin penetration; matrix effects; PAHs