Health & Environmental Research Online (HERO)


30021 
Technical Report 
EPA Report 
Guidelines for neurotoxicity risk assessment 
U.S. Environmental Protection Agency :: U.S. EPA 
1998 
Yes 
U.S. Environmental Protection Agency, Risk Assessment Forum 
Washington, DC 
EPA/630/R-95/001F 
1-89 
89 
English 
is also published as 007582 Guidelines for neurotoxicity risk assessment
The Guidelines for Neurotoxicity Risk Assessment continue the guidelines development process initiated in 1984. These Guidelines set forth principles and procedures to guide EPA scientists in evaluating environmental contaminants that may pose neurotoxic risks, and inform Agency decision makers and the public about these procedures. These Guidelines are the Agency's first statement on setting principles and procedures to guide EPA scientists in conducting neurotoxicity risk assessments. These Guidelines have been developed by a cross-Agency Technical Panel organized by the Risk Assessment Forum.

A link between human exposure to some chemical substances and neurotoxicity has been firmly established. The Guidelines emphasize that risk assessment will be conducted on a case-by-case basis. They stress that information will be fully presented in Agency risk assessment documents and that Agency scientists will identify the strengths and weaknesses of each assessment by describing uncertainties, assumptions, and limitations, as well as the scientific basis and rationale for each assessment. The Guidelines bridge gaps in risk assessment methodology and data by identifying these gaps and the importance of the missing information to the risk assessment process, encouraging research and analysis that will lead to new risk assessment methods and data. The Guidelines specifically note the special vulnerability of the nervous system of infants and children to environmentally relevant chemicals and provide guidance for the interpretation of data from developmental and reproductive studies involving assessment of nervous system structure and function.

The Guidelines help develop a sound scientific basis for neurotoxicity risk assessment and promote consistency in the Agency's assessment of nervous system effects. As in the case of earlier risk assessment guidelines, the principles articulated in these Guidelines will be incorporated into program-specific guidance and procedures. Risk assessment guidelines are not regulations and do not impose legally binding requirements on EPA, states, or the regulated community. 
• Ammonia
     Literature Search – March 2012 (private)
     Literature Search Results
     Not Chemical Specific
          Guidance, notices
• Benzo(a)pyrene (BaP)
     Considered
     Cited
          Guidance
• Biphenyl
     Considered
     Cited References
          Guidance
• tert-Butanol
     Cited in Document
     • Cited 2016 Public Comment Draft
          Tox Review
     Cited in Public Comment Draft – May 2016
          Toxicological Review
• Chloroprene
     Cited 2009 Draft
     Cited 2010 Final
• Chromium VI
     Not in Lit Search
• DCM (Dichloromethane) (Final, 2011)
• 1,4-Dioxane - with inhalation update
     Final (2013)
     External Review Draft (2011)
• Hexabromocyclododecane (HBCD)
     Guidance/contextual references added during assessment development
• Libby Amphibole Asbestos (Draft, 2011)
• Methanol (Non-Cancer)
     Cited in Final (2013)
     Cited in External Review Draft (2013)
     Cited in External Review Draft (2011)
• RDX (121-82-4)
     Cited 2015 (private)
     Guidance documents and contextual references
• Tetrachloroethylene (Perc) (Final, 2012)
     All References
• Trichloroacetic acid (TCA) (Final, 2011)
• Trichloroethylene (TCE) (Final, 2011)
     All References
• Trimethylbenzenes (Interagency Science Discussion Draft)
     Primary Literature Search
     Primary Literature Search- Considered
          Cited
     Cited August 2016
          Cited Toxicological Review
• Trimethylbenzenes (TMB)
     Considered Studies
          Other
     Cited Studies
          Guidance
          EPA
     Cited in Tox Review – Revised TMBs Draft
     Cited in Supplemental Information – Revised TMBs Draft
     Cited in Revised TMBs Draft - All
• Vanadium Pentoxide (Draft, 2011)
NAAQS
• ISA-NOx
     Cited
          2nd Draft
          Final
          Final Cited
• ISA-SOx
     Considered
     Cited in First ERD Nov2015
     Cited Second ERD Dec2016
     Cited in Final ISA Dec2017
          Chapter 5 – Health