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HERO ID
3005418
Reference Type
Journal Article
Title
Relationship between arsenic-containing drinking water and skin cancers in the arseniasis endemic areas in Taiwan
Author(s)
Cheng, PS; Weng, SF; Chiang, CH; Lai, FJ
Year
2015
Is Peer Reviewed?
Yes
Journal
Journal of Dermatology
ISSN:
0385-2407
EISSN:
1346-8138
Volume
43
Issue
2
Page Numbers
181-186
Language
English
PMID
26283637
DOI
10.1111/1346-8138.13058
Web of Science Id
WOS:000369159100010
Abstract
Artesian well-water had high concentrations of arsenic that led to the well-known black foot disease in Taiwan around the 1950s, and the associated cancers including skin cancer, bladder cancers and lung cancers. We sought to estimate the standardized morbidity ratio (SMR) and age-standardized incidence rate (ASIR) of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in the black foot disease endemic areas (BFDEA) in Taiwan. A nationwide retrospective population-based survey was done with the data from the National Taiwan Cancer Registry Center between 1979 and 2007. Among the 29-year period, there were 11 191 cases with SCC and 13 684 cases with BCC diagnosed pathologically. The incidence rates were 4-6-fold higher for SCC and 3-4-fold higher for BCC in the BFDEA compared with the rest of Taiwan. The SMR decreased after stopping arsenic-containing well-water drinking in the 1970s. The arsenic level in the drinking water, amount of contaminated water intake, occupation and sun-exposure time were not documented. This is the first nationwide, population-based study that shows the relationship between arsenic intoxication and non-melanoma skin cancers (SCC and BCC) through comparing the data in people living in the BFDEA and non-BFDEA in Taiwan.
Keywords
arsenic-containing water; basal cell carcinoma; black foot disease endemic area; squamous cell carcinoma; Taiwan
Tags
IRIS
•
Arsenic Hazard ID
Lit Search Updates Oct 2015 to Jan 2019
PubMed
ToxNet
WOS
2.5 Update 2015-2019: Title & Abstract Screening
Considered for further screening
2.5 Update 2015-2019: Full Text Screening Results
Not relevant to PECO
8. Hazard through Oct 2015
Epi Hazard ID
•
Arsenic (Inorganic)
3. Hazard ID Screening
Potentially relevant epidemiology studies
Cited in Volume 2a
Cited in Volume 2b
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