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HERO ID
3008637
Reference Type
Journal Article
Subtype
Review
Title
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
Author(s)
Cao, Y
Year
2015
Volume
9
Issue
3
Page Numbers
261-274
Language
English
PMID
26290283
DOI
10.1007/s11684-015-0406-y
Web of Science Id
WOS:000368445200001
Abstract
Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.
Keywords
environmental pollution; DNA methylation; cancer; biomarker; diagnosis; therapy; prevention
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•
ISA-PM (2019)
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