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HERO ID
3011666
Reference Type
Journal Article
Title
Inflammatory and vasoactive effects of serum following inhalation of varied complex mixtures
Author(s)
Aragon, MJ; Chrobak, I; Brower, J; Roldan, L; Fredenburgh, LE; Mcdonald, JD; Campen, MJ
Year
2015
Is Peer Reviewed?
Yes
Journal
Cardiovascular Toxicology
ISSN:
1530-7905
EISSN:
1559-0259
Volume
16
Issue
2
Page Numbers
163-171
Language
English
PMID
25900702
DOI
10.1007/s12012-015-9325-z
Web of Science Id
WOS:000372228300008
Abstract
Chronic cardiovascular disease is associated with air pollution exposure in epidemiology and toxicology studies. Inhaled toxicants can induce changes in serum bioactivity that impact endothelial inflammatory gene expression in vitro and impair vasorelaxation ex vivo, which are common precursors to atherosclerosis. Comparisons between single pollutants and common combustion mixtures, in terms of driving such serum inflammatory and vasoactive effects, have not been characterized. Healthy C57BL/6 mice were exposed to a single 6-h period of contrasting pollutant atmospheres: road dust, mixed vehicle emissions (MVE; a combination of gasoline and diesel engine emissions) particulate matter, mixed vehicle emissions gases, road dust plus ozone, road dust plus MVE, and hardwood smoke. Serum obtained from mice 24 h after these exposures was used as a stimulus to assess inflammatory potential in two assays: incubated with primary murine cerebrovascular endothelial cells for 4 h to measure inflammatory gene expression or applied to naïve aortic rings in an ex vivo myographic preparation. Road dust and wood smoke exposures were most potent at inducing inflammatory gene expression, while MVE atmospheres and wood smoke were most potent at impairing vasorelaxation to acetylcholine. Responses are consistent with recent reports on MVE toxicity, but reveal novel serum bioactivity related to wood smoke and road dust. These studies suggest that the compositional changes in serum and resultant bioactivity following inhalation exposure to pollutants may be highly dependent on the composition of mixtures.
Keywords
Diesel; Particulate matter; Gasoline; Exhaust; Cardiovascular; Wood smoke; Endothelium
Tags
NAAQS
•
ISA-Ozone (2020 Final Project Page)
Literature Search Results
Literature Search - Included
Keyword Search
Topic Classified Experimental
Title-Abstract Screening (SWIFT-AS) - Excluded
Manually Excluded
•
ISA-PM (2019)
Peer Input Draft
Chapter 6
Considered
1st Draft
Chapter 6
In Scope
Mode of action
ST PM Cardiovascular
LT PM Cardiovascular
ST PM Metabolic
LT PM Metabolic
ST PM Respiratory
LT PM Respiratory
ST PM Nervous
LT PM Nervous
PM Repro-Dev
PM Cancer-Genotox
Final ISA
Chapter 6
•
LitSearch-NOx (2024)
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Epidemiology
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Cardiovascular-ST
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WoS
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PubMed
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Toxicology
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Cardiovascular-LT
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March 2014-November 2016
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