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HERO ID
3022878
Reference Type
Journal Article
Title
Evaluation of 3D-human skin equivalents for assessment of human dermal absorption of some brominated flame retardants
Author(s)
Abdallah, MA; Pawar, G; Harrad, S
Year
2015
Is Peer Reviewed?
1
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Volume
84
Page Numbers
64-70
Language
English
PMID
26232142
DOI
10.1016/j.envint.2015.07.015
Web of Science Id
WOS:000362143600007
URL
http://www.sciencedirect.com/science/article/pii/S0160412015300210
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Abstract
Ethical and technical difficulties inherent to studies in human tissues are impeding assessment of the dermal bioavailability of brominated flame retardants (BFRs). This is further complicated by increasing restrictions on the use of animals in toxicity testing, and the uncertainties associated with extrapolating data from animal studies to humans due to inter-species variations. To overcome these difficulties, we evaluate 3D-human skin equivalents (3D-HSE) as a novel in vitro alternative to human and animal testing for assessment of dermal absorption of BFRs. The percutaneous penetration of hexabromocyclododecanes (HBCD) and tetrabromobisphenol-A (TBBP-A) through two commercially available 3D-HSE models was studied and compared to data obtained for human ex vivo skin according to a standard protocol. No statistically significant differences were observed between the results obtained using 3D-HSE and human ex vivo skin at two exposure levels. The absorbed dose was low (less than 7%) and was significantly correlated with log Kow of the tested BFR. Permeability coefficient values showed increasing dermal resistance to the penetration of γ-HBCD>β-HBCD>α-HBCD>TBBPA. The estimated long lag times (>30min) suggests that frequent hand washing may reduce human exposure to HBCDs and TBBPA via dermal contact.
Keywords
Dermal absorption; Human skin equivalents; Human ex vivo skin; HBCDs; TBBPA; EPISKIN
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
New 7/2016 (private)
Database Searches
Pubmed
WOS
Sources of Mechanistic and Toxicokinetic Data
Toxicokinetic studies
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
Data screening total
Screening: Excluded
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
Total – title/abstract screening
On topic
Peer review
Primary source
Supplemental search
Supplemental other
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
ADME
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