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Citation
Tags
HERO ID
3045345
Reference Type
Journal Article
Title
Modification of seizure activity by electrical stimulation. II. Motor seizure
Author(s)
Racine, RJ
Year
1972
Is Peer Reviewed?
Yes
Journal
Electroencephalography and Clinical Neurophysiology
ISSN:
0013-4694
EISSN:
1872-6380
Volume
32
Issue
3
Page Numbers
281-294
Language
English
PMID
4110397
DOI
10.1016/0013-4694(72)90177-0
Web of Science Id
WOS:A1972L571500007
Abstract
Daily electrical stimulations of the amygdala and hippocampus at intensities sufficient to evoke after-discharges (ADs) resulted in the development of motor seizures, which could not initially be evoked by these stimulations. The triggering of ADs was critical for this development, as well as for the development of permanent changes in the characteristics of the AD. The wave form of the AD “spikes” became more complex. The frequency of these spikes and the duration of AD increased. The amplitude of the AD spikes increased in the structure stimulated as well as in secondary structures to which the AD was “projected”. This increase in amplitude of “projected” spikes often correlated with the appearance of motor seizures. Other electrographic developments are discussed including the appearance of spontaneous “inter-ictal” spiking in the amygdala. It was found that the development of motor seizures by stimulation of the amygdala resulted in an increased ability of the contralateral amygdala, and the septal area, but not of the hippocampus, to drive motor seizures when stimulated (“transfer”). Motor seizure development in the hippocampus transferred to the contralateral hippocampus. These developments were shown, by means of control subjects, with lesions in the primary focus to involve changes outside the primary focus.
Tags
IRIS
•
RDX (121-82-4)
Cited 2015 (private)
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