Journal Article
Exposure to bisphenol A and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell cohort
Casas, M; Valvi, D; Ballesteros-Gomez, A; Gascon, M; Fernández, MF; Garcia-Esteban, R; Iñiguez, C; Martinez, D; Murcia, M; Monfort, N; Luque, N; Rubio, S; Ventura, R; Sunyer, J; Vrijheid, M
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924
US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
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3783662 Personal communication from Maribel Casas to Glinda Cooper and Elizabeth Radke-Farabaugh. Prenatal exposure to phthalates and preterm birth, based on manuscript ""
BACKGROUND: Prenatal exposure to bisphenol A (BPA) and phthalates may affect fetal growth; however, previous findings are inconsistent and based on few studies.
OBJECTIVES: We assessed whether prenatal exposure to BPA and phthalates were associated with fetal growth in a Spanish birth cohort of 488 mother-child pairs.
METHODS: We measured BPA and eight phthalates [four di-2-ethylhexyl phthalate metabolites (DEHPm), mono-benzyl phthalate (MBzP), and three low molecular weight phthalate metabolites (LMWPm)] in two spot-urine samples collected during the first and third trimester of pregnancy. We estimated growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW) during pregnancy (weeks 12-20 and 20-34), and for birth weight, birth length, head circumference at birth, and placental weight.
RESULTS: Overall, results did not support associations between exposure to BPA or DEHPm during pregnancy and fetal growth parameters. Prenatal MBzP exposure was positively associated with FL at 20-34 weeks resulting in an increase of 3.70% of the average FL (95% CI: 0.75, 6.63%) per doubling of MBzP concentration. MBzP was positively associated with birth weight among boys (48 g; 95% CI: 6, 90) but not in girls (-27 g; 95% CI: -79, 25) (interaction p-value = 0.04). The LMWPm mono-n-butyl phthalate (MnBP) was negatively associated with HC at 12-20 pregnancy weeks (-4.88% of HC average [95% CI: -8.36, -1.36%]).
CONCLUSIONS: This study, one of the first to combine repeat exposure biomarker measurements and multiple growth measures during pregnancy, finds little evidence of associations of BPA or phthalate exposures with fetal growth. Phthalate metabolites MBzP and MnBP were associated with some fetal growth parameters, but these findings require replication.
4,4' isopropylidenediphenol; phthalic acid; 4,4' isopropylidenediphenol; benzhydryl derivative; phenol derivative; phthalic acid; phthalic acid derivative; abdominal circumference; adolescent; adult; Article; biparietal distance; birth weight; body mass; controlled study; creatinine urine level; environmental exposure; female; femur; fetus echography; fetus growth; fetus weight; head circumference; human; limit of detection; liquid chromatography; male; placenta weight; pregnancy outcome; pregnant woman; prenatal exposure; priority journal; third trimester pregnancy; urinalysis; adverse effects; cohort analysis; drug effects; environmental exposure; epidemiology; fetomaternal transfusion; fetus development; fetus echography; maternal exposure; newborn; pregnancy; Spain; urine; Adolescent; Adult; Benzhydryl Compounds; Birth Weight; Cohort Studies; Environmental Exposure; Female; Fetal Development; Humans; Infant, Newborn; Male; Maternal Exposure; Maternal-Fetal Exchange; Phenols; Phthalic Acids; Pregnancy; Spain; Ultrasonography, Prenatal
