Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations
Chiu, YM; Hsu, HL; Coull, BA; Bellinger, DC; Kloog, I; Schwartz, J; Wright, RO; Wright, RJ
HERO ID
3055858
Reference Type
Journal Article
Year
2016
Language
English
PMID
| HERO ID | 3055858 |
|---|---|
| In Press | No |
| Year | 2016 |
| Title | Prenatal particulate air pollution and neurodevelopment in urban children: Examining sensitive windows and sex-specific associations |
| Authors | Chiu, YM; Hsu, HL; Coull, BA; Bellinger, DC; Kloog, I; Schwartz, J; Wright, RO; Wright, RJ |
| Journal | Environment International |
| Volume | 87 |
| Page Numbers | 56-65 |
| Abstract | <strong>BACKGROUND: </strong>Brain growth and structural organization occurs in stages beginning prenatally. Toxicants may impact neurodevelopment differently dependent upon exposure timing and fetal sex.<br /><br /><strong>OBJECTIVES: </strong>We implemented innovative methodology to identify sensitive windows for the associations between prenatal particulate matter with diameter≤2.5μm (PM2.5) and children's neurodevelopment.<br /><br /><strong>METHODS: </strong>We assessed 267 full-term urban children's prenatal daily PM2.5 exposure using a validated satellite-based spatio-temporally resolved prediction model. Outcomes included IQ (WISC-IV), attention (omission errors [OEs], commission errors [CEs], hit reaction time [HRT], and HRT standard error [HRT-SE] on the Conners' CPT-II), and memory (general memory [GM] index and its components - verbal [VEM] and visual [VIM] memory, and attention-concentration [AC] indices on the WRAML-2) assessed at age 6.5±0.98years. To identify the role of exposure timing, we used distributed lag models to examine associations between weekly prenatal PM2.5 exposure and neurodevelopment. Sex-specific associations were also examined.<br /><br /><strong>RESULTS: </strong>Mothers were primarily minorities (60% Hispanic, 25% black); 69% had ≤12years of education. Adjusting for maternal age, education, race, and smoking, we found associations between higher PM2.5 levels at 31-38weeks with lower IQ, at 20-26weeks gestation with increased OEs, at 32-36weeks with slower HRT, and at 22-40weeks with increased HRT-SE among boys, while significant associations were found in memory domains in girls (higher PM2.5 exposure at 18-26weeks with reduced VIM, at 12-20weeks with reduced GM).<br /><br /><strong>CONCLUSIONS: </strong>Increased PM2.5 exposure in specific prenatal windows may be associated with poorer function across memory and attention domains with variable associations based on sex. Refined determination of time window- and sex-specific associations may enhance insight into underlying mechanisms and identification of vulnerable subgroups. |
| Doi | 10.1016/j.envint.2015.11.010 |
| Pmid | 26641520 |
| Wosid | WOS:000368951700007 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Air pollution; Prenatal exposure; Particulate matter; Neurodevelopment; Sensitive windows; Sex-specific associations |