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HERO ID
3070943
Reference Type
Journal Article
Title
Dibutyl maleate and dibutyl fumarate enhance contact sensitization to fluorescein isothiocyanate in mice
Author(s)
Matsuoka, T; Kurohane, K; Suzuki, W; Ogawa, E; Kobayashi, K; Imai, Y
Year
2016
Is Peer Reviewed?
Yes
Journal
Biological and Pharmaceutical Bulletin
ISSN:
0918-6158
EISSN:
1347-5215
Book Title
Biol Pharm Bull. 2016; 39(2):272-7. [Biological & pharmaceutical bulletin]
Volume
39
Issue
2
Page Numbers
272-277
Language
English
PMID
26632200
DOI
10.1248/bpb.b15-00683
Web of Science Id
WOS:000369124500016
URL
https://search.proquest.com/docview/1762766149?accountid=171501
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Abstract
Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a butyl alcohol ester of di-carboxylic acid that represents a part of the DBP structure, while di-n-butyl fumarate (DBF) is a trans isomer of DBM. We examined whether DBM or DBF exhibits an adjuvant effect like DBP does. When BALB/c mice were epicutaneously sensitized with FITC in the presence of DBM or DBF, the FITC-specific CHS response was enhanced, as we have observed for DBP. As to underlying mechanisms, DBM and DBF facilitated the trafficking of FITC-presenting CD11c(+) dendritic cells (DCs) from skin to draining lymph nodes and increased the cytokine production by draining lymph nodes. In conclusion, DBM and DBF may have an effect that aggravates contact dermatitis through a skin sensitization process.
Keywords
dibutyl maleate; dibutyl fumarate; adjuvant; contact hypersensitivity; dendritic cell trafficking; cytokine production
Tags
IRIS
•
Dibutyl Phthalate (DBP)
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Phthalates – Targeted Search for Epidemiological Studies
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