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Citation
Tags
HERO ID
3071031
Reference Type
Journal Article
Title
Prenatal Exposures of Male Rats to the Environmental Chemicals Bisphenol A and Di(2-Ethylhexyl) Phthalate Impact the Sexual Differentiation Process
Author(s)
Abdel-Maksoud, FM; Leasor, KR; Butzen, K; Braden, TD; Akingbemi, BT
Year
2015
Is Peer Reviewed?
Yes
Journal
Endocrinology
ISSN:
0013-7227
EISSN:
1945-7170
Volume
156
Issue
12
Page Numbers
4672-4683
Language
English
PMID
26372177
DOI
10.1210/en.2015-1077
Web of Science Id
WOS:000368410900027
Abstract
The increasing incidence of reproductive anomalies, described as testicular dysgenesis syndrome, is thought to be related to the exposure of the population to chemicals in the environment. Bisphenol A (BPA) and di(2-ethylhexyl)phthalate (DEHP), which have hormonal and antihormonal activity, have attracted public attention due to their presence in consumer products. The present study investigated the effects of BPA and DEHP on reproductive development. Timed-pregnant female rats were exposed to BPA and DEHP by gavage from gestational days 12 to 21. Results showed that prenatal exposures to test chemicals exerted variable effects on steroidogenic factor 1 and GATA binding protein 4 protein expression and increased (P < .05) sex-determining region Y-box 9 and antimüllerian hormone protein in the infantile rat testis compared with levels in the control unexposed animals. Pituitary LHβ and FSHβ subunit protein expression was increased (P < .05) in BPA- and DEHP-exposed prepubertal male rats but were decreased (P < .05) in adult animals relative to control. Exposure to both BPA and DEHP in utero inhibited (P < .05) global DNA hydroxymethylation in the adult testis in association with altered DNA methyltransferase protein expression. Together the present data suggest that altered developmental programming in the testes associated with chemical exposures are related to the disruption of sexual differentiation events and DNA methylation patterns. The chemical-induced effects impact the development of steroidogenic capacity in the adult testis.
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Excluded: No Primary Data on Health Effects
Not chemical specific
Use in sample prep or assay
Litsearch June 2015 - Jan 2016
Pubmed
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
Excluded
Source - Jun 2016 Update (Private)
Pubmed
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