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Citation
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HERO ID
3123389
Reference Type
Journal Article
Title
Introduction of an alpha,beta-unsaturated carbonyl conjugated pyrene-lactose hybrid as a fluorescent molecular probe for micro-scale anisotropic media
Author(s)
Sarkar, Ivy; Hemamalini, A; Das, TM; Mishra, AK
Year
2016
Is Peer Reviewed?
1
Journal
RSC Advances
EISSN:
2046-2069
Publisher
Royal Society of Chemistry
Volume
6
Issue
33
Page Numbers
27933-27943
Language
English
DOI
10.1039/c5ra26146e
Web of Science Id
WOS:000372644100076
Abstract
A new fluorescent lactose molecule (pyd-lact) (E)-1-(galactose-β-(1â4)-β-d-glucopyranosyl)-4-(1-pyrene)-but-3-en-2-one, has been synthesized by attaching 1-pyrene-but-3-ene-2-one to lactose. Extended Ï-conjugation removes the emission forbiddenness of pyrene, which results in the broad spectrum. Detailed photo-physical studies in homogeneous media show the sensitivity of ICT (intra molecular charge transfer) emission towards medium polarity. Unlike pyrene, pyd-lact is more soluble in water at a probe concentration of 10 μM, because of the attached disaccharide. Thus, the usage of pyd-lact as an aqueous probe is found to be advantageous over pyrene. Using the polarity sensitivity of fluorescence parameters (intensity, shift of emission maximum, anisotropy, lifetime), the micro-heterogeneity of anisotropic media such as β-CD, bile salts, and Pluronic P123 have been monitored. In contrast to pyrene-3-carboxaldehyde, which is often used as a hydrophobic fluorescent molecular probe, pyd-lact reports from the interfacial regions of micro-heterogeneous media. © 2016 The Royal Society of Chemistry.
Tags
IRIS
•
Ammonia, Oral - Problem Formulation
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