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Journal Article 
Acute impact of hourly ambient air pollution on preterm birth 
Li, S; Guo, Y; Williams, G 
Environmental Health Perspectives
ISSN: 0091-6765
EISSN: 1552-9924 
is supplemented by 3449404 - Supplementary material
BACKGROUND: Preterm birth is a major perinatal health problem but factors leading to it are still not completely understood.

OBJECTIVES: To identify the relation between acute increase in ambient air pollution in a few hours before onset of labour and the risk of preterm birth.

METHODS: We collected registered birth outcome data and hourly ambient air pollution measurements during 2009 ‒ 2013 in Brisbane, Australia. Using the time-stratified case-crossover design and conditional logistic regression models with natural cubic splines, we assessed the shape of air pollution ‒ preterm birth curve, after controlling for potential confounders. We also examined the effect modification of other factors.

RESULTS: The association between air pollution [nitrogen dioxide (NO2), sulphur dioxide (SO2), and carbon monoxide (CO)] and preterm birth was non-linear. Threshold concentrations for the mean of 0 ‒ 24 hours NO2, 24 ‒ 48 hours SO2, and 24 ‒ 48 hours CO before onset of labour were 7.6 parts per billion (ppb), 3.8 ppb, and 162.5 ppb, respectively. Increases in air pollution concentrations above thresholds were associated with increased risks of preterm birth. The ORs of preterm birth at 95th percentile of NO2, SO2 and CO against the thresholds were 1.17 (1.08, 1.27), 1.01 (0.99, 1.04), and 1.18 (1.06, 1.32), respectively. The associations were modified by demographic factors, for example, maternal smoking and socioeconomic status (SES).

CONCLUSION: Acute increases in ambient air pollution concentrations above certain levels before onset of labour may stimulate preterm birth. 
     Cited Second ERD Dec2016
     Cited in Final ISA Dec2017
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