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HERO ID
3230370
Reference Type
Journal Article
Title
Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy
Author(s)
Johns, LE; Ferguson, KK; Mcelrath, TF; Mukherjee, B; Meeker, JD
Year
2016
Is Peer Reviewed?
Yes
Journal
Environmental Health Perspectives
ISSN:
0091-6765
EISSN:
1552-9924
Volume
124
Issue
11
Page Numbers
1808-1815
Language
English
PMID
27152641
DOI
10.1289/EHP170
Web of Science Id
WOS:000386913800027
URL
https://ehp.niehs.nih.gov/doi/10.1289/EHP170
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Abstract
BACKGROUND:
Maintaining thyroid homeostasis during pregnancy is essential for normal fetal growth and development. Growing evidence suggests that phthalates interfere with normal thyroid function. Few human studies have investigated the degree to which phthalates may affect thyroid hormone levels in particularly susceptible populations such as pregnant women.
OBJECTIVES:
We examined the associations between repeated measures of urinary phthalate metabolites and plasma thyroid hormone levels in samples collected at up to four time points per subject in pregnancy. Additionally, we investigated the potential windows of susceptibility to thyroid hormone disturbances related to study visit of sample collection.
METHODS:
Data were obtained from pregnant women (N=439) participating in a nested case-control study of preterm birth with 116 cases and 323 controls. We measured 9 phthalate metabolite concentrations in urine samples collected at up to four study visits per subject during pregnancy (median= 10, 18, 26, and 35 weeks of gestation, respectively). We also measured a panel of thyroid function markers in plasma collected at the same four time points per subject during pregnancy.
RESULTS:
While our results were generally null, in repeated measures analyses we observed that phthalate metabolites were largely inversely associated with thyrotropin (TSH) and positively associated with free and total thyroid hormones. Cross-sectional analyses by study visit revealed that the magnitude and/or direction of these relationships varied by timing of exposure during gestation.
CONCLUSIONS:
These results support previous reports showing the potential for environmental phthalate exposure to alter circulating levels of thyroid hormones in pregnant women.
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
Pubmed
Studies with Health Effects Data
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DBP
DiBP
BBP
DEP
Source - Jun 2016 Update (Private)
Pubmed
Source - Dec 2016 Update (Private)
Pubmed
WOS
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