US EPA

3230389 

Journal Article 

Follicular fluid and urinary concentrations of phthalate metabolites among infertile women and associations with in vitro fertilization parameters 

Du, YY; Fang, YL; Wang, YX; Zeng, Q; Guo, N; Zhao, H; Li, YF 

2016 

1 

Reproductive Toxicology
ISSN: 0890-6238
EISSN: 1873-1708 

61 

142-150 

English 

27067915 

10.1016/j.reprotox.2016.04.005 

WOS:000377926500017 

https://search.proquest.com/docview/1808687800?accountid=171501
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Evidence from toxicological studies has demonstrated that phthalates can lead to reduced fertility through effects on folliculogenesis, oocyte maturation and embryonic development, but human data are limited. Concentrations of eight phthalate metabolites in 110 follicular fluid (FF) and urine samples collected from 112 women attending an infertility clinic in Wuhan, China were quantified, and correlations between paired matrices were explored. Associations between metabolite concentrations and in vitro fertilization (IVF) parameters were evaluated with multivariable models. Six metabolites were detected in >72.73% of the FF samples. MEHP and MBP were the dominant metabolites with a median level of 2.80 and 2.05ng/mL, respectively. Significant correlations between the two matrices, urine and FF, were found for MEP (rs=0.44), and MBP (rs=0.22). FF and urinary metabolite concentrations were not associated with any IVF parameters. However, given the prevalence of phthalates exposure, further work is needed to elucidate the potential hazard on female reproduction. 

Phthalates; Follicular fluid; IVF parameters; Female reproduction; Endocrine disruptors