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Citation
Tags
HERO ID
3230537
Reference Type
Journal Article
Subtype
Review
Title
The non-genomic effects of endocrine-disrupting chemicals on mammalian sperm
Author(s)
Tavares, RS; Escada-Rebelo, S; Correia, M; Mota, PC; Ramalho-Santos, J
Year
2016
Is Peer Reviewed?
1
Journal
Reproduction
ISSN:
1470-1626
EISSN:
1741-7899
Volume
151
Issue
1
Page Numbers
R1-R13
Language
English
PMID
26585413
DOI
10.1530/REP-15-0355
Web of Science Id
WOS:000368732200001
Abstract
Exposure to toxicants present in the environment, especially the so-called endocrine-disrupting chemicals (EDCs), has been associated with decreased sperm quality and increased anomalies in male reproductive organs over the past decades. Both human and animal populations are continuously exposed to ubiquitous synthetic and natural-occurring EDCs through diet, dermal contact and/or inhalation, therefore potentially compromising male reproductive health. Although the effects of EDC are likely induced via multiple genomic-based pathways, their non-genomic effects may also be relevant. Furthermore, spermatozoa are transcriptionally inactive cells that can come in direct contact with EDCs in reproductive fluids and secretions and are therefore a good model to address non-genomic effects. This review thus focuses on the non-genomic effects of several important EDCs relevant to mammalian exposure. Notably, EDCs were found to interfere with pre-existing pathways inducing a panoply of deleterious effects to sperm function that included altered intracellular Ca(2) (+) oscillations, induction of oxidative stress, mitochondrial dysfunction, increased DNA damage and decreased sperm motility and viability, among others, potentially jeopardizing male fertility. Although many studies have used non-environmentally relevant concentrations of only one compound for mechanistic studies, it is important to remember that mammals are not exposed to one, but rather to a multitude of environmental EDCs, and synergistic effects may occur. Furthermore, some effects have been detected with single compounds at environmentally relevant concentrations.
Tags
IRIS
•
PCBs
Supplemental
Targeted review search
Source
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
WOS
Excluded
Source - Jun 2016 Update (Private)
WOS
Source - Dec 2016 Update (Private)
WOS
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