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HERO ID
3230560
Reference Type
Journal Article
Title
Adverse effect of DEHP exposure on the serum insulin level of Balb/c mice
Author(s)
Wang, J; Li, J; Zahid, KR; Wang, Kun; Qian, Yan; Ma, P; Ding, S; Yang, Xu; Wang, X
Year
2016
Is Peer Reviewed?
1
Journal
Molecular & Cellular Toxicology
ISSN:
1738-642X
EISSN:
2092-8467
Publisher
Springer Verlag
Location
GYEONGGI-DO
Volume
12
Issue
1
Page Numbers
83-91
Language
English
DOI
10.1007/s13273-016-0011-4
Web of Science Id
WOS:000373095200011
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962052783&doi=10.1007%2fs13273-016-0011-4&partnerID=40&md5=afbf5363f0a66dafca5e875d13ff8704
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Abstract
Di(2-ethylhexyl) phthalate (DEHP) is a common indoor pollutant in the world, which may cause lots of harmful effects in human including diabetes according to epidemiological studies. To explore the underlying role of DEHP in diabetes-like symptoms, Balb/c mice were chose to be the experimental animals in this paper. They were separated as eight groups as follows: (1) saline + normal diet (vehicle control), (2) 10 mg/kg.day DEHP + normal diet, (3) 50 mg/kg.day DEHP + normal diet, (4) 250 mg/kg.day DEHP + normal diet, (5) streptozotocin (STZ) + high fat diet (diabetes model), (6) 10 mg/kg.day DEHP + STZ + high fat diet, (7) 50 mg/kg.day DEHP + STZ + high fat diet, (8) 250 mg/kg.day DEHP + STZ + high fat diet. The biomarkers of this experiment include four groups: (1) general indicates: body weight and drinking water, (2) blood biomarkers: serum insulin and fasting glucose, (3) pathological examination: pancreas section and kidney section, and (4) biomarkers of oxidative stress: reactive oxygen species (ROS) and malondialdehyde (MDA) in liver cells. Our study results demonstrate that: (1) at our treatment levels DEHP cannot directly induce diabetes, but reduce serum insulin level in DEHP-exposed non-STZ-treated animals, (2) pathological examination finds that these is a dose -dependent damage in the pancreas in DE HP-exposed STZ-treated groups, and (3) the oxidative mechanism may be involved in this pathological process.
Keywords
DEHP exposure; Diabetes-like symptom; Insulin; Blood glucose; Pancreatic cell; Oxidative stress
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
WOS
Excluded
Source - Jun 2016 Update (Private)
WOS
Source - Dec 2016 Update (Private)
WOS
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