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Citation
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HERO ID
3252
Reference Type
Journal Article
Title
The impact of litter effects on dose-response modeling in teratology
Author(s)
Kupper, LL; Poetier, C; Hogan, MD; Yamamoto, E
Year
1986
Is Peer Reviewed?
Yes
Journal
Biometrics
ISSN:
0006-341X
EISSN:
1541-0420
Volume
42
Issue
1
Page Numbers
85-98
Language
English
PMID
3719065
DOI
10.2307/2531245
Web of Science Id
WOS:A1986C904700007
URL
http://www.jstor.org/stable/2531245
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Abstract
The fitting of dose-response models to teratology data involving littermates in order to generate estimates of teratogenic risk is receiving increasing attention as a potential alternative to the "safety-factor" approach to risk estimation. In this paper, we utilize the beta-binomial distribution to introduce varying degrees of intralitter correlation, and, for purposes of illustration, consider a logistic dose-response model that describes the logit of risk as a straight-line function of ln(dose). The biases and (exact and asymptotic) variances of the maximum likelihood estimators of the intercept and slope are studied by simulation as a function of the intralitter correlation structure.
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