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Citation
Tags
HERO ID
3350206
Reference Type
Journal Article
Title
Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis
Author(s)
Watkins, DJ; Milewski, S; Domino, SE; Meeker, JD; Padmanabhan, V
Year
2016
Is Peer Reviewed?
1
Journal
Reproductive Toxicology
ISSN:
0890-6238
EISSN:
1873-1708
Publisher
Elsevier Inc.
Location
OXFORD
Volume
65
Page Numbers
59-66
Language
English
PMID
27352641
DOI
10.1016/j.reprotox.2016.06.021
Web of Science Id
WOS:000385990900008
URL
https://search.proquest.com/docview/1837326211?accountid=171501
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Abstract
Epidemiologic studies of in utero phthalate exposure and birth outcomes have had conflicting findings. The objective of this study was to characterize maternal phthalate exposure across pregnancy, examine associations between maternal phthalate levels and infant size and gestational age at birth, and investigate relationships between concurrent bisphenol A (BPA) and phthalate exposure and birth outcomes. Women in the Michigan Mother-Infant Pairs cohort provided urine and blood samples during their first trimester and at delivery. Urinary phthalate metabolites and serum BPA were measured at both time points, and birth weight, length, head circumference, and gestational age were recorded from medical records. Maternal DEHP metabolite concentrations were significantly higher at delivery compared to the first trimester (p<0.05), suggesting increased DEHP exposure late in pregnancy. A number of phthalate metabolites were associated with birth size and gestational age in patterns that varied by sex and timing of exposure, independent of BPA exposure.
Keywords
Phthalates; Bisphenol A; In utero; Exposure; Birth weight; Gestational age
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
Pubmed
LitSearch Jul 2016 - Jan 2017
Prior search overlap
WoS
Studies with Supporting Data
Mechanistic and genotoxicity studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DBP
DiBP
BBP
DEP
Source - Dec 2016 Update (Private)
Pubmed
WOS
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