Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3350252
Reference Type
Journal Article
Subtype
Supplemental Data
Title
Persistent organic pollutants and promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene : Supplemental materials
Author(s)
Park, SY; Kim, KS; Lee, YM; Kim, MJ; Jacobs, DR; Porta, M; Kim, DS; Lee, DH
Year
2015
Is Peer Reviewed?
Yes
Journal
Biomarkers
ISSN:
1354-750X
EISSN:
1366-5804
Volume
20
Issue
2
Page Numbers
136-142
Language
English
Relationship(s)
is a supplement to
2920037
Persistent organic pollutants and promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene
Abstract
Promoter hypermethylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) DNA repair gene is important during carcinogenesis. We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer. Hypermethylation decreased as OCPs increased (Ptrend = 0.02), while PCB concentrations showed an inverted U-shaped association (Pquadratic < 0.01). The prevalence of MGMT promoter hypermethylation was highest within the 2nd quintile of the PCB summary score (28.4%), while it was only 2.7% in the upper 10% score. Chronic exposure to these chemicals may affect methylation of the MGMT promoter, with possibly non-monotonic dose response relationships.
Tags
IRIS
•
PCBs
Litsearches
Remaining
LitSearch August 2015
Pubmed
Toxline
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity