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HERO ID
3350495
Reference Type
Journal Article
Title
Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats
Author(s)
Miller, I; Serchi, T; Cambier, S; Diepenbroek, C; Renaut, J; Van der Berg, JH; Kwadijk, C; Gutleb, AC; Rijntjes, E; Murk, AJ
Year
2016
Is Peer Reviewed?
1
Journal
Toxicology Letters
ISSN:
0378-4274
EISSN:
1879-3169
Volume
245
Page Numbers
40-51
Language
English
PMID
26795019
DOI
10.1016/j.toxlet.2016.01.002
Web of Science Id
WOS:000369941000006
Abstract
Hexabromocyclododecane (HBCD) is a brominated flame retardant known for its low acute toxicity as observed in animal experiments. However, HBCD exposure can affect liver functioning and thyroid hormone (TH) status. As exact mechanisms are unknown and only limited toxicological data exists, a gel-based proteomic approach was undertaken. In a eu- and hypothyroid female rat model, rats were exposed to 3 and 30 mg/kg bw/day HBCD for 7 days via their diet, and exposure was related to a range of canonical endpoints (hormone status, body weight) available for these animals. Alterations in the liver proteome under HBCD exposure were determined in comparison with patterns of control animals, for both thyroid states. This revealed significantly changed abundance of proteins involved in metabolic processes (gluconeogenesis/glycolysis, amino acid metabolism, lipid metabolism), but also in oxidative stress responses, in both euthyroid and hypothyroid rats. The results provide a more detailed picture on the mechanisms involved in these alterations, e.g. at the protein level changes of the proposed influence of HBCD on the lipid metabolism. Present results show that proteomic approaches can provide further mechanistic insights in toxicological studies.
Keywords
HBCD; Proteomics; Rat; Liver; Hypothyroidism; Lipid metabolism
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
New 7/2016 (private)
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Pubmed
WOS
Sources of Mechanistic and Toxicokinetic Data
Mechanistic and genotoxicity studies
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
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On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Animal hazard ID
MOA
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