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Citation
Tags
HERO ID
3350503
Reference Type
Journal Article
Title
Indoor pollutant hexabromocyclododecane has a modest immunomodulatory effect on house dust mite induced allergic asthma in mice
Author(s)
Canbaz, D; Logiantara, A; Hamers, T; van Ree, R; van Rijt, LS
Year
2016
Is Peer Reviewed?
Yes
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Volume
50
Issue
1
Page Numbers
405-411
Language
English
PMID
26633745
DOI
10.1021/acs.est.5b05348
Web of Science Id
WOS:000367866300046
Abstract
Hexabromocyclododecane (HBCD) has been recognized as an indoor pollutant. HBCD is added as a flame retardant to many consumer products and leaches from the products into house dust. HBCD might be potentially hazardous to the airways because of inhalation of house dust. Sensitization to house dust mite (HDM) is a risk factor for the development of allergic asthma. In this study, we examined whether HBCD can affect the immune response to HDM allergens. Bone-marrow-derived dendritic cells (BMDCs) were exposed simultaneously to HBCD and HDM in vitro. HBCD enhanced oxidative stress in HDM-pulsed BMDCs, which was accompanied by a higher production of Interleukin (IL)-6 and -10. Adoptive transfer of HDM/HBCD-exposed BMDCs into naı̈ve mice resulted in enhanced levels of IL-17A after inhalational challenge with HDM. Direct mucosal exposure to HBCD during HDM inhalation enhanced IL-4 or IL-17A production, depending on the HDM extract used, but did not aggravate the eosinophilic airway inflammation or airway hyper-reactivity. Our results indicate that exposure to HBCD can have a mild immune-modulating effect by enhancing the inflammatory cytokine production in response to inhaled HDM in mice.
Keywords
HUMAN HEALTH
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
New 7/2016 (private)
Database Searches
Pubmed
Sources of Mechanistic and Toxicokinetic Data
Mechanistic and genotoxicity studies
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
Data screening total
Screening: Excluded
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
MOA
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