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Citation
Tags
HERO ID
3350939
Reference Type
Journal Article
Title
Common environmental chemicals do not explain atopy contrast in the Finnish and Russian Karelia
Author(s)
Koskinen, JP; Kiviranta, H; Vartiainen, E; Jousilahti, P; Vlasoff, T; von Hertzen, L; Mäkelä, M; Laatikainen, T; Haahtela, T
Year
2016
Is Peer Reviewed?
Yes
Journal
Clinical and Translational Allergy
ISSN:
2045-7022
Volume
6
Page Numbers
14
Language
English
PMID
27047657
DOI
10.1186/s13601-016-0103-1
Web of Science Id
WOS:000390114800001
Abstract
BACKGROUND:
Atopic allergy is much more common in Finnish compared with Russian Karelia, although these areas are geographically and genetically close. To explore the role of environmental chemicals on the atopy difference a random sample of 200 individuals, 25 atopic and 25 non-atopic school-aged children and their mothers, were studied. Atopy was defined as having at least one positive skin prick test response to 14 common inhalant and food allergens tested. Concentrations of 11 common environmental pollutants were measured in blood samples.
RESULTS:
Overall, the chemical levels were much higher in Russia than in Finland, except for 2,2',4,4'-tetra-bromodiphenyl ether (BDE47). In Finland but not in Russia, the atopic children had higher concentrations of polychlorinated biphenyls and 1,1-Dichloro-2,2-bis-(p-chlorophenyl)-ethylene (DDE) than the non-atopic children. In Russia but not in Finland, the atopic mothers had higher DDE concentrations than the non-atopic mothers.
CONCLUSIONS:
Higher concentrations of common environmental chemicals were measured in Russian compared with Finnish Karelian children and mothers. The chemicals did not explain the higher prevalence of atopy on the Finnish side.
Tags
IRIS
•
PCBs
Hazard ID: Epidemiological evidence
Litsearches
Litsearch Aug 2015 - Aug 2016
Pubmed
•
PCBs Epi Hazard ID
Health Effects
Immunological
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