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HERO ID
3357864
Reference Type
Journal Article
Subtype
Review
Title
The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma
Author(s)
Spann, K; Snape, N; Baturcam, E; Fantino, E
Year
2016
Volume
82
Issue
1
Page Numbers
28-40
Language
English
PMID
27325066
DOI
10.1016/j.aogh.2016.01.007
Web of Science Id
WOS:000378067000005
Abstract
The airway epithelium is both a physical barrier protecting the airways from environmental insults and a significant component of the innate immune response. There is growing evidence that exposure of the airway epithelium to environmental insults in early life may lead to permanent changes in structure and function that underlie the development of asthma. Here we review the current published evidence concerning the link between asthma and epithelial damage within the airways and identify gaps in knowledge for future studies.
Keywords
asthma; allergens; air pollution; virus; epithelium; early life; airway remodeling; immunity
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